A novel classification of lung cancer into molecular subtypes.
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ABSTRACT:
SUBMITTER: West L
PROVIDER: S-EPMC3283716 | biostudies-other | 2012
REPOSITORIES: biostudies-other
Publications
A novel classification of lung cancer into molecular subtypes.
West Lisandra L Vidwans Smruti J SJ Campbell Nicholas P NP Shrager Jeff J Simon George R GR Bueno Raphael R Dennis Phillip A PA Otterson Gregory A GA Salgia Ravi R
PloS one 20120221 2
The remarkably heterogeneous nature of lung cancer has become more apparent over the last decade. In general, advanced lung cancer is an aggressive malignancy with a poor prognosis. The discovery of multiple molecular mechanisms underlying the development, progression, and prognosis of lung cancer, however, has created new opportunities for targeted therapy and improved outcome. In this paper, we define "molecular subtypes" of lung cancer based on specific actionable genetic aberrations. Each su ...[more]
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