Ontology highlight
ABSTRACT:
SUBMITTER: Valentin-Vega YA
PROVIDER: S-EPMC3286212 | biostudies-other | 2012 Feb
REPOSITORIES: biostudies-other
Blood 20111205 6
Ataxia-telangiectasia mutated (ATM) plays a central role in DNA damage responses, and its loss leads to development of T-cell malignancies. Here, we show that ATM loss also leads to intrinsic mitochondrial abnormalities in thymocytes, including elevated reactive oxygen species, increased aberrant mitochondria, high cellular respiratory capacity, and decreased mitophagy. A fraction of ATM protein is localized in mitochondria, and it is rapidly activated by mitochondrial dysfunction. Unexpectedly, ...[more]