Ontology highlight
ABSTRACT:
SUBMITTER: Singh P
PROVIDER: S-EPMC3286345 | biostudies-other | 2012 Feb
REPOSITORIES: biostudies-other
Singh Pratibha P Hoggatt Jonathan J Hu Peirong P Speth Jennifer M JM Fukuda Seiji S Breyer Richard M RM Pelus Louis M LM
Blood 20111122 7
Dendritic cell (DC) homeostasis, like all mature blood cells, is maintained via hierarchal generation from hematopoietic precursors; however, little is known about the regulatory mechanisms governing DC generation. Here, we show that prostaglandin E(2) (PGE(2)) is required for optimal Flt3 ligand-mediated DC development and regulates expression of the Flt3 receptor on DC-committed progenitor cells. Inhibition of PGE(2) biosynthesis reduces Flt3-mediated activation of STAT3 and expression of the ...[more]