Ontology highlight
ABSTRACT:
SUBMITTER: Ramamoorthy M
PROVIDER: S-EPMC3287182 | biostudies-other | 2012 Feb
REPOSITORIES: biostudies-other
Ramamoorthy Mahesh M Tadokoro Takashi T Rybanska Ivana I Ghosh Avik K AK Wersto Robert R May Alfred A Kulikowicz Tomasz T Sykora Peter P Croteau Deborah L DL Bohr Vilhelm A VA
Nucleic acids research 20111019 4
DNA decatenation mediated by Topoisomerase II is required to separate the interlinked sister chromatids post-replication. SGS1, a yeast homolog of the human RecQ family of helicases interacts with Topoisomerase II and plays a role in chromosome segregation, but this functional interaction has yet to be identified in higher organisms. Here, we report a physical and functional interaction of Topoisomerase IIα with RECQL5, one of five mammalian RecQ helicases, during DNA replication. Direct interac ...[more]