Ontology highlight
ABSTRACT:
SUBMITTER: He S
PROVIDER: S-EPMC3287904 | biostudies-other | 2011
REPOSITORIES: biostudies-other
BMC proceedings 20111129
In genome-wide association studies, gene-based methods measure potential joint genetic effects of loci within genes and are promising for detecting causative genetic variations. Following recent theoretical research in statistical multiple-hypothesis testing, we propose to adapt the Higher Criticism procedures to develop novel gene-based methods that use the information of linkage disequilibrium for detecting weak and sparse genetic signals. With the large-scale exonic single-nucleotide polymorp ...[more]