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Asthma and lung cancer risk: a systematic investigation by the International Lung Cancer Consortium.


ABSTRACT: Asthma has been hypothesized to be associated with lung cancer (LC) risk. We conducted a pooled analysis of 16 studies in the International Lung Cancer Consortium (ILCCO) to quantitatively assess this association and compared the results with 36 previously published studies. In total, information from 585?444 individuals was used. Study-specific measures were combined using random effects models. A meta-regression and subgroup meta-analyses were performed to identify sources of heterogeneity. The overall LC relative risk (RR) associated with asthma was 1.28 [95% confidence intervals (CIs) = 1.16-1.41] but with large heterogeneity (I(2) = 73%, P < 0.001) between studies. Among ILCCO studies, an increased risk was found for squamous cell (RR = 1.69, 95%, CI = 1.26-2.26) and for small-cell carcinoma (RR = 1.71, 95% CI = 0.99-2.95) but was weaker for adenocarcinoma (RR = 1.09, 95% CI = 0.88-1.36). The increased LC risk was strongest in the 2 years after asthma diagnosis (RR = 2.13, 95% CI = 1.09-4.17) but subjects diagnosed with asthma over 10 years prior had no or little increased LC risk (RR = 1.10, 95% CI = 0.94-1.30). Because the increased incidence of LC was chiefly observed in small cell and squamous cell lung carcinomas, primarily within 2 years of asthma diagnosis and because the association was weak among never smokers, we conclude that the association may not reflect a causal effect of asthma on the risk of LC.

SUBMITTER: Rosenberger A 

PROVIDER: S-EPMC3291861 | biostudies-other | 2012 Mar

REPOSITORIES: biostudies-other

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Asthma and lung cancer risk: a systematic investigation by the International Lung Cancer Consortium.

Rosenberger Albert A   Bickeböller Heike H   McCormack Valerie V   Brenner Darren R DR   Duell Eric J EJ   Tjønneland Anne A   Friis Soren S   Muscat Joshua E JE   Yang Ping P   Wichmann H-Erich HE   Heinrich Joachim J   Szeszenia-Dabrowska Neonila N   Lissowska Jolanta J   Zaridze David D   Rudnai Peter P   Fabianova Eleonora E   Janout Vladimir V   Bencko Vladimir V   Brennan Paul P   Mates Dana D   Schwartz Ann G AG   Cote Michele L ML   Zhang Zuo-Feng ZF   Morgenstern Hal H   Oh Sam S SS   Field John K JK   Raji Olaide O   McLaughlin John R JR   Wiencke John J   LeMarchand Loic L   Neri Monica M   Bonassi Stefano S   Andrew Angeline S AS   Lan Qing Q   Hu Wei W   Orlow Irene I   Park Bernard J BJ   Boffetta Paolo P   Hung Rayjean J RJ  

Carcinogenesis 20111222 3


Asthma has been hypothesized to be associated with lung cancer (LC) risk. We conducted a pooled analysis of 16 studies in the International Lung Cancer Consortium (ILCCO) to quantitatively assess this association and compared the results with 36 previously published studies. In total, information from 585 444 individuals was used. Study-specific measures were combined using random effects models. A meta-regression and subgroup meta-analyses were performed to identify sources of heterogeneity. Th  ...[more]

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