Unknown

Dataset Information

0

MicroRNA-1/133a and microRNA-206/133b clusters: dysregulation and functional roles in human cancers.


ABSTRACT: MicroRNAs (miRNAs) are endogenous short non-coding RNA molecules that regulate gene expression by repressing translation or cleaving RNA transcripts in a sequence-specific manner. A growing body of evidence suggests that miRNAs are aberrantly expressed in many human cancers and that they play significant roles in the initiation, development and metastasis of human cancers. Genome-wide miRNA expression signatures provide information on the aberrant expression of miRNAs in cancers rapidly and precisely. Recently, studies from our group and others revealed that microRNA-1 (miR-1), microRNA-133a (miR-133a), microRNA-133b?(miR-133b) and microRNA-206 (miR-206) are frequently downregulated in various types of cancers. Interestingly, miR-1-1/miR-133a-2,?miR-1-2/miR-133a-1, and miR-206/miR-133b form clusters in three different chromosomal regions of the human genome - 20q13.33, 18q11.2 and 6p12.1, respectively. Here we review highlights of recent findings on the aberrant expression and functional significance of?the miR-1/miR-133a and miR-206/miR-133b clusters in human cancers.

SUBMITTER: Nohata N 

PROVIDER: S-EPMC3292888 | biostudies-other | 2012 Jan

REPOSITORIES: biostudies-other

altmetric image

Publications

microRNA-1/133a and microRNA-206/133b clusters: dysregulation and functional roles in human cancers.

Nohata Nijiro N   Hanazawa Toyoyuki T   Enokida Hideki H   Seki Naohiko N  

Oncotarget 20120101 1


MicroRNAs (miRNAs) are endogenous short non-coding RNA molecules that regulate gene expression by repressing translation or cleaving RNA transcripts in a sequence-specific manner. A growing body of evidence suggests that miRNAs are aberrantly expressed in many human cancers and that they play significant roles in the initiation, development and metastasis of human cancers. Genome-wide miRNA expression signatures provide information on the aberrant expression of miRNAs in cancers rapidly and prec  ...[more]

Similar Datasets

| S-EPMC7596429 | biostudies-literature
| S-EPMC8347974 | biostudies-literature
| S-EPMC9021824 | biostudies-literature
| S-EPMC7724490 | biostudies-literature
| S-EPMC3825415 | biostudies-literature
2022-03-22 | E-MTAB-10229 | biostudies-arrayexpress
| S-EPMC3900797 | biostudies-literature
| S-EPMC4240597 | biostudies-literature
| S-EPMC8640450 | biostudies-literature
| S-EPMC9758816 | biostudies-literature