Ontology highlight
ABSTRACT:
SUBMITTER: Zacharoff L
PROVIDER: S-EPMC3293115 | biostudies-other | 2012 Mar
REPOSITORIES: biostudies-other
Zacharoff Lori L Tkac Ivan I Song Qingfeng Q Tang Chuanning C Bolan Patrick J PJ Mangia Silvia S Henry Pierre-Gilles PG Li Tongbin T Dubinsky Janet M JM
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20111102 3
To improve the ability to move from preclinical trials in mouse models of Huntington's disease (HD) to clinical trials in humans, biomarkers are needed that can track similar aspects of disease progression across species. Brain metabolites, detectable by magnetic resonance spectroscopy (MRS), have been suggested as potential biomarkers in HD. In this study, the R6/2 transgenic mouse model of HD was used to investigate the relative sensitivity of the metabolite profiling and the brain volumetry t ...[more]