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Clarithromycin monohydrate: a synchrotron X-ray powder study.


ABSTRACT: In the crystal structure of the title compound, clarithromycin (CAM) monohydrate, C(38)H(69)NO(13)·H(2)O, the water mol-ecule behaves as a proton donor and is hydrogen bonded to the hy-droxy O atom of the CAM cladinose ring. The hy-droxy O atom also behaves as a proton donor, forming an inter-molecular hydrogen bond with one of the hy-droxy groups of the 14-membered aglycone ring. The CAM mol-ecules are linked through these hydrogen bonds into chains running parallel to the c axis.

SUBMITTER: Noguchi S 

PROVIDER: S-EPMC3295456 | biostudies-other | 2012 Mar

REPOSITORIES: biostudies-other

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Clarithromycin monohydrate: a synchrotron X-ray powder study.

Noguchi Shuji S   Fujiki Sadahiro S   Iwao Yasunori Y   Miura Keiko K   Itai Shigeru S  

Acta crystallographica. Section E, Structure reports online 20120210 Pt 3


In the crystal structure of the title compound, clarithromycin (CAM) monohydrate, C(38)H(69)NO(13)·H(2)O, the water mol-ecule behaves as a proton donor and is hydrogen bonded to the hy-droxy O atom of the CAM cladinose ring. The hy-droxy O atom also behaves as a proton donor, forming an inter-molecular hydrogen bond with one of the hy-droxy groups of the 14-membered aglycone ring. The CAM mol-ecules are linked through these hydrogen bonds into chains running parallel to the c axis. ...[more]

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