SPECT/CT imaging of hNIS-expression after intravenous delivery of an oncolytic adenovirus and 131I.
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ABSTRACT:
SUBMITTER: Rajecki M
PROVIDER: S-EPMC3296755 | biostudies-other | 2012
REPOSITORIES: biostudies-other
Publications
SPECT/CT imaging of hNIS-expression after intravenous delivery of an oncolytic adenovirus and 131I.
Rajecki Maria M Sarparanta Mirkka M Hakkarainen Tanja T Tenhunen Mikko M Diaconu Iulia I Kuhmonen Venla V Kairemo Kalevi K Kanerva Anna A Airaksinen Anu J AJ Hemminki Akseli A
PloS one 20120307 3
Oncolytic adenoviruses can be engineered for better tumor selectivity, gene delivery and be armed for imaging and concentrating radionuclides into tumors for synergistic oncolysis. We constructed Ad5/3-hTERT-hNIS where replication is controlled by hTERT-promoter. Ad5/3-hTERT-hNIS expresses hNIS for imaging of transgene expression and for treatment of infected tumors by radioiodine. Ad5/3-hTERT-hNIS efficiently killed prostate cancer cells and induced iodine uptake in vitro and in vivo after intr ...[more]
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