Ontology highlight
ABSTRACT:
SUBMITTER: Shulman J
PROVIDER: S-EPMC3297814 | biostudies-other | 2011 Dec
REPOSITORIES: biostudies-other
Biophysical journal 20111201 11
Circadian rhythms are governed by a highly coupled, complex network of genes. Due to feedback within the network, any modification of the system's state requires coherent changes in several nodes. A model of the underlying network is necessary to compute these modifications. We use an effective modeling approach for this task. Rather than inferred biochemical interactions, our method utilizes microarray data from a group of mutants for its construction. With simulated data, we develop an effecti ...[more]