Unknown

Dataset Information

0

Independent effects of HIV, aging, and HAART on brain volumetric measures.


ABSTRACT: Neurocognitive impairment remains prevalent in HIV-infected (HIV+) individuals despite highly active antiretroviral therapy (HAART). We assessed the impact of HIV, HAART, and aging using structural neuroimaging.Seventy-eight participants [HIV- (n = 26), HIV+ on stable HAART (HIV+/HAART+; n = 26), HIV+ naive to HAART (HIV+/HAART-; n = 26)] completed neuroimaging and neuropsychological testing. A subset of HIV+ subjects (n = 12) performed longitudinal assessments before and after initiating HAART. Neuropsychological tests evaluated memory, psychomotor speed, and executive function, and a composite neuropsychological score was calculated based on normalized performances (neuropsychological summary Z score, NPZ-4). Volumetrics were evaluated for the amygdala, caudate, thalamus, hippocampus, putamen, corpus callosum, and cerebral gray and white matter. A 3-group 1-way analysis of variance assessed differences in neuroimaging and neuropsychological indices. Correlations were examined between NPZ-4 and volumetrics. Exploratory testing using a broken-stick regression model evaluated self-reported duration of HIV infection on brain structure.HIV+ individuals had significant reductions in brain volumetrics within select subcortical regions (amygdala, caudate, and corpus callosum) compared with HIV- participants. However, HAART did not affect brain structure as regional volumes were similar for HIV+/HAART- and HIV+/HAART+. No association existed between NPZ-4 and volumetrics. HIV and aging were independently associated with volumetric reductions. Exploratory analyses suggest caudate atrophy due to HIV slowly occurs after self-reported seroconversion.HIV associated volumetric reductions within the amygdala, caudate, and corpus callosum occurs despite HAART. A gradual decline in caudate volume occurs after self-reported seroconversion. HIV and aging independently increase brain vulnerability. Additional longitudinal structural magnetic resonance imaging studies, especially within older HIV+ participants, are required.

SUBMITTER: Ances BM 

PROVIDER: S-EPMC3302928 | biostudies-other | 2012 Apr

REPOSITORIES: biostudies-other

altmetric image

Publications

Independent effects of HIV, aging, and HAART on brain volumetric measures.

Ances Beau M BM   Ortega Mario M   Vaida Florin F   Heaps Jodi J   Paul Robert R  

Journal of acquired immune deficiency syndromes (1999) 20120401 5


<h4>Background</h4>Neurocognitive impairment remains prevalent in HIV-infected (HIV+) individuals despite highly active antiretroviral therapy (HAART). We assessed the impact of HIV, HAART, and aging using structural neuroimaging.<h4>Methods</h4>Seventy-eight participants [HIV- (n = 26), HIV+ on stable HAART (HIV+/HAART+; n = 26), HIV+ naive to HAART (HIV+/HAART-; n = 26)] completed neuroimaging and neuropsychological testing. A subset of HIV+ subjects (n = 12) performed longitudinal assessments  ...[more]

Similar Datasets

| S-EPMC5340610 | biostudies-literature
| S-EPMC3082694 | biostudies-literature
2011-03-26 | GSE28177 | GEO
2011-03-25 | E-GEOD-28177 | biostudies-arrayexpress
| S-EPMC8219192 | biostudies-literature
| S-EPMC8105496 | biostudies-literature
| S-EPMC3154580 | biostudies-literature
| S-EPMC7806781 | biostudies-literature
| S-EPMC5315270 | biostudies-literature
| S-EPMC3280054 | biostudies-literature