Ontology highlight
ABSTRACT:
SUBMITTER: Zhou L
PROVIDER: S-EPMC3308827 | biostudies-other | 2012 Mar
REPOSITORIES: biostudies-other
Zhou Lei L Jones Emma V EV Murai Keith K KK
The Journal of biological chemistry 20120126 12
Actin cytoskeletal remodeling plays a critical role in transforming the morphology of subcellular structures across various cell types. In the brain, restructuring of dendritic spines through actin cytoskeleletal reorganization is implicated in the regulation of synaptic efficacy and the storage of information in neural circuits. However, the upstream pathways that provoke actin-based spine changes remain only partly understood. Here we show that EphA receptor signaling remodels spines by trigge ...[more]