All subgenomic mRNAs of equine arteritis virus contain a common leader sequence.
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ABSTRACT:
SUBMITTER: de Vries AA
PROVIDER: S-EPMC330929 | biostudies-other | 1990 Jun
REPOSITORIES: biostudies-other
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All subgenomic mRNAs of equine arteritis virus contain a common leader sequence.
de Vries A A AA Chirnside E D ED Bredenbeek P J PJ Gravestein L A LA Horzinek M C MC Spaan W J WJ
Nucleic acids research 19900601 11
During the replication of equine arteritis virus (EAV) six subgenomic mRNAs are synthesized. We present evidence that the viral mRNAs form a 3'-coterminal nested set and contain a common leader sequence of 208 nucleotides which is encoded by the 5'-end of the genome. The leader is joined to the bodies of mRNA 5 and 6 at positions defined by the sequence 5' UCAAC 3'. The part of the leader sequence flanking the UCAAC motif is very similar to the 5'-splice site of the Tetrahymena pre-rRNA. A possi ...[more]
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