Ontology highlight
ABSTRACT:
SUBMITTER: Tsutsui Y
PROVIDER: S-EPMC3311335 | biostudies-other | 2012 Mar
REPOSITORIES: biostudies-other
Tsutsui Yuko Y Dela Cruz Richard R Wintrode Patrick L PL
Proceedings of the National Academy of Sciences of the United States of America 20120305 12
The misfolding of serpins is linked to several genetic disorders including emphysema, thrombosis, and dementia. During folding, inhibitory serpins are kinetically trapped in a metastable state in which a stretch of residues near the C terminus of the molecule are exposed to solvent as a flexible loop (the reactive center loop). When they inhibit target proteases, serpins transition to a stable state in which the reactive center loop forms part of a six-stranded β-sheet. Here, we use hydrogen-deu ...[more]