Ontology highlight
ABSTRACT:
SUBMITTER: Izawa T
PROVIDER: S-EPMC3315801 | biostudies-other | 2012 Apr
REPOSITORIES: biostudies-other
Izawa Toshiaki T Nagai Hiroyuki H Endo Toshiya T Nishikawa Shuh-ichi S
Molecular biology of the cell 20120201 7
The endoplasmic reticulum (ER) has an elaborate quality control system, which retains misfolded proteins and targets them to ER-associated protein degradation (ERAD). To analyze sorting between ER retention and ER exit to the secretory pathway, we constructed fusion proteins containing both folded carboxypeptidase Y (CPY) and misfolded mutant CPY (CPY*) units. Although the luminal Hsp70 chaperone BiP interacts with the fusion proteins containing CPY* with similar efficiency, a lectin-like ERAD f ...[more]