"Point" centromeres of Saccharomyces harbor single centromere-specific nucleosomes.
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ABSTRACT:
SUBMITTER: Henikoff S
PROVIDER: S-EPMC3316665 | biostudies-other | 2012 Apr
REPOSITORIES: biostudies-other
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"Point" centromeres of Saccharomyces harbor single centromere-specific nucleosomes.
Henikoff Steven S Henikoff Jorja G JG
Genetics 20120110 4
The "point" centromere of budding yeast is genetically defined by an ≈ 125-bp sequence. Recent fluorescence measurements of kinetochore clusters have suggested that this sequence specifies multiple centromere histone 3 (CenH3) nucleosomes. However, high-resolution mapping demonstrates that there is only one CenH3 nucleosome per centromere, providing biochemical confirmation of the point centromere model. ...[more]
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