Ontology highlight
ABSTRACT:
SUBMITTER: Mazin A
PROVIDER: S-EPMC331959 | biostudies-other | 1994 Oct
REPOSITORIES: biostudies-other
Mazin A A Timchenko T T Ménissier-de Murcia J J Schreiber V V Angulo J F JF de Murcia G G Devoret R R
Nucleic acids research 19941001 20
Kin17 is a 45 kDa protein encoded by the KIN17 gene located on mouse chromosome 2, band A. The kin17 amino acid sequence predicts two domains, which were shown to be functional: (i) a bipartite nuclear localization signal (NLS) that can drive the protein to the cell nucleus, (ii) a bona fide zinc finger of the C2H2 type. The zinc finger is involved in kin17 binding to double-stranded DNA since a mutant deleted of the zinc finger, kin17 delta 1, showed reduced binding. Single-stranded DNA was bou ...[more]