Ontology highlight
ABSTRACT:
SUBMITTER: Ali AM
PROVIDER: S-EPMC3321854 | biostudies-other | 2012 Apr
REPOSITORIES: biostudies-other
Ali Abdullah Mahmood AM Pradhan Arun A Singh Thiyam Ramsingh TR Du Changhu C Li Jie J Wahengbam Kebola K Grassman Elke E Auerbach Arleen D AD Pang Qishen Q Meetei Amom Ruhikanta AR
Blood 20120217 14
Fanconi anemia (FA) nuclear core complex is a multiprotein complex required for the functional integrity of the FA-BRCA pathway regulating DNA repair. This pathway is inactivated in FA, a devastating genetic disease, which leads to hematologic defects and cancer in patients. Here we report the isolation and characterization of a novel 20-kDa FANCA-associated protein (FAAP20). We show that FAAP20 is an integral component of the FA nuclear core complex. We identify a region on FANCA that physicall ...[more]