Ontology highlight
ABSTRACT:
SUBMITTER: Fazly A
PROVIDER: S-EPMC3322881 | biostudies-other | 2012 Mar
REPOSITORIES: biostudies-other
The Journal of biological chemistry 20120215 14
The yeast histone chaperone Rtt106 is involved in de novo assembly of newly synthesized histones into nucleosomes during DNA replication and plays a role in regulating heterochromatin silencing and maintaining genomic integrity. The interaction of Rtt106 with H3-H4 is modulated by acetylation of H3 lysine 56 catalyzed by the lysine acetyltransferase Rtt109. Using affinity purification strategies, we demonstrate that Rtt106 interacts with (H3-H4)(2) heterotetramers in vivo. In addition, we show t ...[more]