Ontology highlight
ABSTRACT:
SUBMITTER: Shen F
PROVIDER: S-EPMC3323197 | biostudies-other | 2011 Dec
REPOSITORIES: biostudies-other
Shen Fanxia F Walker Espen J EJ Jiang Lidan L Degos Vincent V Li Jianping J Sun Baoliang B Heriyanto Fransisca F Young William L WL Su Hua H
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20110720 12
Vascular endothelial growth factor (VEGF)-induced neovasculature is immature and leaky. We tested if coexpression of angiopoietin-1 (ANG1) with VEGF improves blood-brain barrier (BBB) integrity and VEGF neuroprotective and neurorestorative effects using a permanent distal middle cerebral artery occlusion (pMCAO) model. Adult CD-1 mice were injected with 2 × 10(9) virus genomes of adeno-associated viral vectors expressing VEGF (AAV-VEGF) or ANG1 (AAV-ANG1) individually or together in a 1:1 ratio ...[more]