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Walking motion of an overdamped active particle in a ratchet potential.

ABSTRACT: An active particle can convert its internal energy into mechanical work. We study a generalized energy-depot model of an overdamped active particle in a ratchet potential. Using well-known biological parameters for kinesin-1 and modeling ATP influx as a pulsed energy supply, we apply our model to the molecular motor system. We find that our simple model can capture the essential properties of the kinesin motor such as forward stepping, stalling, backward stepping, dependence on ATP concentration, and stall force. Our model might be quite universal in the sense that it is able to describe dynamics of various types of motors as long as realistic parameters for each motor species are adopted.

SUBMITTER: Lee KJ

PROVIDER: S-EPMC3326151 | biostudies-other | 2012 Mar

REPOSITORIES: biostudies-other

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Walking motion of an overdamped active particle in a ratchet potential.

Lee Kong-Ju-Bock KJ Kim Chul Koo CK Chung Myung-Hoon MH

Journal of biological physics 20111202 2

An active particle can convert its internal energy into mechanical work. We study a generalized energy-depot model of an overdamped active particle in a ratchet potential. Using well-known biological parameters for kinesin-1 and modeling ATP influx as a pulsed energy supply, we apply our model to the molecular motor system. We find that our simple model can capture the essential properties of the kinesin motor such as forward stepping, stalling, backward stepping, dependence on ATP concentration ...[more]

PMID: 23449554

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