Ontology highlight
ABSTRACT:
SUBMITTER: Xi S
PROVIDER: S-EPMC3327128 | biostudies-other | 2009 Nov
REPOSITORIES: biostudies-other
Xi Sichuan S Geiman Theresa M TM Briones Victorino V Guang Tao Yong Y Xu Hong H Muegge Kathrin K
Stem cells (Dayton, Ohio) 20091101 11
Transcriptional control of stem cell genes is a critical step in differentiation of embryonic stem cells and in reprogramming of somatic cells into stem cells. Here we report that Lsh, a regulator of repressive chromatin at retrotransposons, also plays an important role in silencing of stem cell-specific genes such as Oct4. We found that CpG methylation is gained during in vitro differentiation of several stem cell-specific genes (in 11 of 12 promoter regions) and thus appears to be a common epi ...[more]