Ontology highlight
ABSTRACT:
SUBMITTER: Gerhart-Hines Z
PROVIDER: S-EPMC3331675 | biostudies-other | 2011 Dec
REPOSITORIES: biostudies-other
Gerhart-Hines Zachary Z Dominy John E JE Blättler Sharon M SM Jedrychowski Mark P MP Banks Alexander S AS Lim Ji-Hong JH Chim Helen H Gygi Steven P SP Puigserver Pere P
Molecular cell 20111201 6
The NAD(+)-dependent deacetylase SIRT1 is an evolutionarily conserved metabolic sensor of the Sirtuin family that mediates homeostatic responses to certain physiological stresses such as nutrient restriction. Previous reports have implicated fluctuations in intracellular NAD(+) concentrations as the principal regulator of SIRT1 activity. However, here we have identified a cAMP-induced phosphorylation of a highly conserved serine (S434) located in the SIRT1 catalytic domain that rapidly enhanced ...[more]