Ontology highlight
ABSTRACT:
SUBMITTER: Goncalves MA
PROVIDER: S-EPMC3333848 | biostudies-other | 2012 Apr
REPOSITORIES: biostudies-other
Gonçalves Manuel A F V MA van Nierop Gijsbert P GP Holkers Maarten M de Vries Antoine A F AA
Nucleic acids research 20111220 8
The exchange of genetic information between donor and acceptor DNA molecules by homologous recombination (HR) depends on the cleavage of phosphodiester bonds. Although double-stranded and single-stranded DNA breaks (SSBs) have both been invoked as triggers of HR, until very recently the focus has been primarily on the former type of DNA lesions mainly due to the paucity of SSB-based recombination models. Here, to investigate the role of nicked DNA molecules as HR-initiating substrates in human s ...[more]