Ontology highlight
ABSTRACT:
SUBMITTER: Renouf B
PROVIDER: S-EPMC3333856 | biostudies-other | 2012 Apr
REPOSITORIES: biostudies-other
Renouf Benjamin B Soret Christine C Saandi Thoueiba T Delalande François F Martin Elisabeth E Vanier Marie M Duluc Isabelle I Gross Isabelle I Freund Jean-Noël JN Domon-Dell Claire C
Nucleic acids research 20111220 8
Cdx2, a gene of the paraHox cluster, encodes a homeodomain transcription factor that plays numerous roles in embryonic development and in homeostasis of the adult intestine. Whereas Cdx2 exerts a tumor suppressor function in the gut, its abnormal ectopic expression in acute leukemia is associated to a pro-oncogenic function. To try to understand this duality, we have hypothesized that Cdx2 may interact with different protein partners in the two tissues and set up experiments to identify them by ...[more]