Ontology highlight
ABSTRACT:
SUBMITTER: Lim CJ
PROVIDER: S-EPMC3333869 | biostudies-other | 2012 Apr
REPOSITORIES: biostudies-other
Lim Ci Ji CJ Whang Yixun R YR Kenney Linda J LJ Yan Jie J
Nucleic acids research 20111219 8
Nucleoid-associated proteins are bacterial proteins that are responsible for chromosomal DNA compaction and global gene regulation. One such protein is Escherichia coli Histone-like nucleoid structuring protein (H-NS) which functions as a global gene silencer. Whereas the DNA-binding mechanism of H-NS is well-characterized, its paralogue, StpA which is also able to silence genes is less understood. Here we show that StpA is similar to H-NS in that it is able to form a rigid filament along DNA. I ...[more]