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Multilayer DNA origami packed on hexagonal and hybrid lattices.

ABSTRACT: "Scaffolded DNA origami" has been proven to be a powerful and efficient approach to construct two-dimensional or three-dimensional objects with great complexity. Multilayer DNA origami has been demonstrated with helices packing along either honeycomb-lattice geometry or square-lattice geometry. Here we report successful folding of multilayer DNA origami with helices arranged on a close-packed hexagonal lattice. This arrangement yields a higher density of helical packing and therefore higher resolution of spatial addressing than has been shown previously. We also demonstrate hybrid multilayer DNA origami with honeycomb-lattice, square-lattice, and hexagonal-lattice packing of helices all in one design. The availability of hexagonal close-packing of helices extends our ability to build complex structures using DNA nanotechnology.

SUBMITTER: Ke Y 

PROVIDER: S-EPMC3336742 | biostudies-other | 2012 Jan

REPOSITORIES: biostudies-other

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Multilayer DNA origami packed on hexagonal and hybrid lattices.

Ke Yonggang Y   Voigt Niels V NV   Gothelf Kurt V KV   Shih William M WM  

Journal of the American Chemical Society 20120113 3

"Scaffolded DNA origami" has been proven to be a powerful and efficient approach to construct two-dimensional or three-dimensional objects with great complexity. Multilayer DNA origami has been demonstrated with helices packing along either honeycomb-lattice geometry or square-lattice geometry. Here we report successful folding of multilayer DNA origami with helices arranged on a close-packed hexagonal lattice. This arrangement yields a higher density of helical packing and therefore higher reso  ...[more]