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Paradigms and Controversies in the Treatment of HIV-Related Burkitt Lymphoma.

ABSTRACT: Burkitt lymphoma (BL) is a very aggressive subtype of non-Hodgkin's lymphoma that occurs with higher frequency in patients with HIV/AIDS. Patients with HIV-related BL (HIV-BL) are usually treated with high-intensity, multi-agent chemotherapy regimens. The addition of the monoclonal antibody Rituximab to chemotherapy has also been studied in this setting. The potential risks and benefits of commonly used regimens are reviewed herein, along with a discussion of controversial issues in the practical management of HIV-BL, including concurrent anti-retroviral therapy, treatment of relapsed and/or refractory disease, and the role of stem cell transplantation.

SUBMITTER: Petrich AM

PROVIDER: S-EPMC3337598 | biostudies-other | 2012

REPOSITORIES: biostudies-other

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Paradigms and Controversies in the Treatment of HIV-Related Burkitt Lymphoma.

Petrich Adam M AM Sparano Joseph A JA Parekh Samir S

Advances in hematology 20120418

Burkitt lymphoma (BL) is a very aggressive subtype of non-Hodgkin's lymphoma that occurs with higher frequency in patients with HIV/AIDS. Patients with HIV-related BL (HIV-BL) are usually treated with high-intensity, multi-agent chemotherapy regimens. The addition of the monoclonal antibody Rituximab to chemotherapy has also been studied in this setting. The potential risks and benefits of commonly used regimens are reviewed herein, along with a discussion of controversial issues in the practica ...[more]

PMID: 22570659

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