Ontology highlight
ABSTRACT:
SUBMITTER: Zhou S
PROVIDER: S-EPMC3338872 | biostudies-other | 2012 Apr
REPOSITORIES: biostudies-other
Zhou Shaohua S Lo Wing-Cheong WC Suhalim Jeffrey L JL Digman Michelle A MA Gratton Enrico E Nie Qing Q Lander Arthur D AD
Current biology : CB 20120322 8
<h4>Background</h4>How morphogen gradients form has long been a subject of controversy. The strongest support for the view that morphogens do not simply spread by free diffusion has come from a variety of studies of the Decapentaplegic (Dpp) gradient of the Drosophila larval wing disc.<h4>Results</h4>In the present study, we initially show how the failure, in such studies, to consider the coupling of transport to receptor-mediated uptake and degradation has led to estimates of transport rates th ...[more]