Ontology highlight
ABSTRACT:
SUBMITTER: Chan KT
PROVIDER: S-EPMC3339874 | biostudies-other | 2012 May
REPOSITORIES: biostudies-other
Chan Keefe T KT Roadcap David W DW Holoweckyj Nicholas N Bear James E JE
The Biochemical journal 20120501 1
Dynamic rearrangement of actin filament networks is critical for cell motility, phagocytosis and endocytosis. Coronins facilitate these processes, in part, by their ability to bind F-actin (filamentous actin). We previously identified a conserved surface-exposed arginine (Arg(30)) in the β-propeller of Coronin 1B required for F-actin binding in vitro and in vivo. However, whether this finding translates to other coronins has not been well defined. Using quantitative actin-binding assays, we show ...[more]