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41-Azido-41-de-oxy-rapamycin.

ABSTRACT: The title compound, C(51)H(78)N(4)O(12), is a derivative of rapamycin, a triene macrolide anti-biotic mol-ecule isolated from Streptomyces hygroscopicus. The macrocyclic ring structure has 15 chiral centres, with one of the substituent hy-droxy groups giving an intra-molecular hydrogen bond to a ketone O-atom acceptor. The mol-ecules also form inter-molecular hy-droxy-ketone O-H?O hydrogen-bonding associations, giving one-dimensional chains extending along (010). The crystal has 108?Å(3) solvent-accessible voids.

SUBMITTER: Xie L

PROVIDER: S-EPMC3344143 | biostudies-other | 2012 Apr

REPOSITORIES: biostudies-other

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41-Azido-41-de-oxy-rapamycin.

Xie Lijun L Huang Jie J Zuo Jian J Yu Hui H Cheng Yuanrong Y

Acta crystallographica. Section E, Structure reports online 20120328 Pt 4

The title compound, C(51)H(78)N(4)O(12), is a derivative of rapamycin, a triene macrolide anti-biotic mol-ecule isolated from Streptomyces hygroscopicus. The macrocyclic ring structure has 15 chiral centres, with one of the substituent hy-droxy groups giving an intra-molecular hydrogen bond to a ketone O-atom acceptor. The mol-ecules also form inter-molecular hy-droxy-ketone O-H⋯O hydrogen-bonding associations, giving one-dimensional chains extending along (010). The crystal has 108 Å(3) solvent ...[more]

PMID: 22606146

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