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6-Methyl-ideneandrost-4-ene-3,17-dione.

ABSTRACT: In the title compound, C(20)H(26)O(2), which is the 6-methyl-ene derivative of androstenedione and a synthetic percursor of exemestane, the steroid A ring approximates to a sofa (or envelope) conformation, with the methyl-ene group adjacent to the link to the B ring lying out of the plane of the other atoms. The B and C rings have slightly flattened chair conformations and the D ring is an envelope, with the CH group forming the flap. In the crystal, mol-ecules are linked by two distinct C-H?O hydrogen bonds, involving acidic H atoms close to C=C and C=O double bonds.

SUBMITTER: Andrade LC

PROVIDER: S-EPMC3344189 | biostudies-other | 2012 Apr

REPOSITORIES: biostudies-other

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6-Methyl-ideneandrost-4-ene-3,17-dione.

Andrade L C R LC de Almeida M J M MJ Fernandes Roleira F M FM Varela C L CL Tavares da Silva E J EJ

Acta crystallographica. Section E, Structure reports online 20120331 Pt 4

In the title compound, C(20)H(26)O(2), which is the 6-methyl-ene derivative of androstenedione and a synthetic percursor of exemestane, the steroid A ring approximates to a sofa (or envelope) conformation, with the methyl-ene group adjacent to the link to the B ring lying out of the plane of the other atoms. The B and C rings have slightly flattened chair conformations and the D ring is an envelope, with the CH group forming the flap. In the crystal, mol-ecules are linked by two distinct C-H⋯O h ...[more]

PMID: 22606192

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