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Vaccines against drug abuse.

ABSTRACT: The currently available medications for the treatment of drug abuse have had only limited success. Anti-addiction vaccines, aimed at eliciting antibodies that block the pharmacological effects of drugs, have great potential for treating drug abuse. We review the status of two vaccines that are undergoing clinical trials (for cocaine and nicotine addiction) and two that are still in preclinical development (for methamphetamine and heroin addiction). We also outline the challenges and ethical concerns associated with the development of anti-addiction vaccines and their use as future therapeutics.

SUBMITTER: Shen XY 

PROVIDER: S-EPMC3345810 | biostudies-other | 2012 Jan

REPOSITORIES: biostudies-other

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Vaccines against drug abuse.

Shen X Y XY   Orson F M FM   Kosten T R TR  

Clinical pharmacology and therapeutics 20111130 1

The currently available medications for the treatment of drug abuse have had only limited success. Anti-addiction vaccines, aimed at eliciting antibodies that block the pharmacological effects of drugs, have great potential for treating drug abuse. We review the status of two vaccines that are undergoing clinical trials (for cocaine and nicotine addiction) and two that are still in preclinical development (for methamphetamine and heroin addiction). We also outline the challenges and ethical conc  ...[more]

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