Ontology highlight
ABSTRACT:
SUBMITTER: Luxenburg C
PROVIDER: S-EPMC3346827 | biostudies-other | 2012 Apr
REPOSITORIES: biostudies-other
Luxenburg Chen C Winograd-Katz Sabina S Addadi Lia L Geiger Benjamin B
Journal of cell science 20120210 Pt 7
Podosomes, which are formed by different monocyte derivatives, are small adhesion structures whose coordinated dynamics and cytoskeletal reorganization drive their motile and invasive features. Using live-cell microscopy, we explored the temporal molecular steps of the de novo assembly and disassembly of podosomes in cultured osteoclasts. We demonstrate here that the earliest visible step in podosome assembly is the local accumulation of the plaque protein paxillin, along with cortactin, which s ...[more]