Ontology highlight
ABSTRACT:
SUBMITTER: Sertel S
PROVIDER: S-EPMC3349672 | biostudies-other | 2012
REPOSITORIES: biostudies-other
Sertel Serkan S Tome Margaret M Briehl Margaret M MM Bauer Judith J Hock Kai K Plinkert Peter K PK Efferth Thomas T Efferth Thomas T
PloS one 20120510 5
Previously, arsenic trioxide showed impressive regression rates of acute promyelocytic leukemia. Here, we investigated molecular determinants of sensitivity and resistance of cell lines of different tumor types towards arsenic trioxide. Arsenic trioxide was the most cytotoxic compound among 8 arsenicals investigated in the NCI cell line panel. We correlated transcriptome-wide microarray-based mRNA expression to the IC(50) values for arsenic trioxide by bioinformatic approaches (COMPARE and hiera ...[more]