Ontology highlight
ABSTRACT:
SUBMITTER: Trusko SP
PROVIDER: S-EPMC335129 | biostudies-other | 1989 Nov
REPOSITORIES: biostudies-other
Trusko S P SP Hoffman E K EK George D L DL
Nucleic acids research 19891101 22
Enhanced expression of the cKi-ras proto-oncogene in a bone marrow-derived mouse cell line, 416B, has been shown to be associated with the integration of Friend viral DNA into the cellular gene. Here we report the results of experiments designed to clarify the molecular mechanism responsible for the cKi-ras overexpression. Based on primer extension analyses and DNA sequencing of cKi-ras cDNA clones, we have obtained evidence that the 416B cells contain viral-host chimaeric transcripts that initi ...[more]