The analysis of the human hemopexin promoter defines a new class of liver-specific genes.
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ABSTRACT:
SUBMITTER: Poli V
PROVIDER: S-EPMC335137 | biostudies-other | 1989 Nov
REPOSITORIES: biostudies-other
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The analysis of the human hemopexin promoter defines a new class of liver-specific genes.
Poli V V Silengo L L Altruda F F Cortese R R
Nucleic acids research 19891101 22
Hemopexin (Hpx) is a plasma glycoprotein which is expressed only in the liver. It is synthesized at a lower rate in the fetal liver than in the adult, and its level increases during acute infections. As shown here, a fragment of the human hemopexin promoter spanning from positions -130 to +22 relative to the cap site is sufficient to direct cell-specific transcription of a reporter gene. Within this segment a short sequence, located between positions -120 and -104, is responsible for this effect ...[more]
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