Ontology highlight
ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC3351814 | biostudies-other | 2012 Jun
REPOSITORIES: biostudies-other
Liu Jingjing J Liang Shuang S Liu Xiaoxi X Brown J Andrew JA Newman Kylie E KE Sunkara Manjula M Morris Andrew J AJ Bhatnagar Saloni S Li Xiangan X Pujol Aurora A Graf Gregory A GA
Journal of lipid research 20120406 6
ABCD2 (D2) is a peroxisomal transporter that is highly abundant in adipose tissue and promotes the oxidation of long-chain MUFA. Erucic acid (EA, 22:1ω9) reduces very long chain saturated fatty acids in patients with X-linked adrenoleukodystrophy but promotes dyslipidemia and dilated cardiomyopathy in rats. To determine the role of D2 in the metabolism of EA, we challenged wild-type and D2 deficient mice (D2 KO) with an enriched EA diet. In D2 KO mice, dietary EA resulted in the rapid expansion ...[more]