Ontology highlight
ABSTRACT:
SUBMITTER: Casiraghi C
PROVIDER: S-EPMC3355105 | biostudies-other | 2012
REPOSITORIES: biostudies-other
Casiraghi Costanza C Shanina Iryna I Cho Sehyun S Freeman Michael L ML Blackman Marcia A MA Horwitz Marc S MS
PLoS pathogens 20120517 5
Epstein-Barr virus (EBV) has been identified as a putative environmental trigger of multiple sclerosis (MS), yet EBV's role in MS remains elusive. We utilized murine gamma herpesvirus 68 (γHV-68), the murine homolog to EBV, to examine how infection by a virus like EBV could enhance CNS autoimmunity. Mice latently infected with γHV-68 developed more severe EAE including heightened paralysis and mortality. Similar to MS, γHV-68EAE mice developed lesions composed of CD4 and CD8 T cells, macrophages ...[more]