Unknown

Dataset Information

0

Gammaherpesvirus latency accentuates EAE pathogenesis: relevance to Epstein-Barr virus and multiple sclerosis.


ABSTRACT: Epstein-Barr virus (EBV) has been identified as a putative environmental trigger of multiple sclerosis (MS), yet EBV's role in MS remains elusive. We utilized murine gamma herpesvirus 68 (?HV-68), the murine homolog to EBV, to examine how infection by a virus like EBV could enhance CNS autoimmunity. Mice latently infected with ?HV-68 developed more severe EAE including heightened paralysis and mortality. Similar to MS, ?HV-68EAE mice developed lesions composed of CD4 and CD8 T cells, macrophages and loss of myelin in the brain and spinal cord. Further, T cells from the CNS of ?HV-68 EAE mice were primarily Th1, producing heightened levels of IFN-? and T-bet accompanied by IL-17 suppression, whereas a Th17 response was observed in uninfected EAE mice. Clearly, ?HV-68 latency polarizes the adaptive immune response, directs a heightened CNS pathology following EAE induction reminiscent of human MS and portrays a novel mechanism by which EBV likely influences MS and other autoimmune diseases.

SUBMITTER: Casiraghi C 

PROVIDER: S-EPMC3355105 | biostudies-other | 2012

REPOSITORIES: biostudies-other

altmetric image

Publications

Gammaherpesvirus latency accentuates EAE pathogenesis: relevance to Epstein-Barr virus and multiple sclerosis.

Casiraghi Costanza C   Shanina Iryna I   Cho Sehyun S   Freeman Michael L ML   Blackman Marcia A MA   Horwitz Marc S MS  

PLoS pathogens 20120517 5


Epstein-Barr virus (EBV) has been identified as a putative environmental trigger of multiple sclerosis (MS), yet EBV's role in MS remains elusive. We utilized murine gamma herpesvirus 68 (γHV-68), the murine homolog to EBV, to examine how infection by a virus like EBV could enhance CNS autoimmunity. Mice latently infected with γHV-68 developed more severe EAE including heightened paralysis and mortality. Similar to MS, γHV-68EAE mice developed lesions composed of CD4 and CD8 T cells, macrophages  ...[more]

Similar Datasets

| S-EPMC9362539 | biostudies-literature
| S-EPMC3764840 | biostudies-literature
| S-EPMC6456696 | biostudies-literature
| S-EPMC6957475 | biostudies-literature
| S-EPMC7335184 | biostudies-literature
| S-EPMC4388746 | biostudies-literature
| S-EPMC7106557 | biostudies-literature
| S-EPMC2118531 | biostudies-literature
| S-EPMC3806908 | biostudies-literature
| S-EPMC5649756 | biostudies-literature