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Senescence in chronic obstructive pulmonary disease.

ABSTRACT: There is a growing realization that chronic obstructive pulmonary disease involves several processes present in aging and cellular senescence. The impact of these processes in the pathogenesis of the main manifestations is multiple, particularly in the propagation of a proinflammatory phenotype, loss of reparative potential, and amplification of oxidative stress, all ultimately leading to tissue damage. This review highlights salient aspects related to senescence discussed in the 2011 Aspen Lung Conference.

SUBMITTER: Tuder RM

PROVIDER: S-EPMC3359109 | biostudies-other | 2012 May

REPOSITORIES: biostudies-other

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Senescence in chronic obstructive pulmonary disease.

Tuder Rubin M RM Kern Jeffrey A JA Miller York E YE

Proceedings of the American Thoracic Society 20120501 2

There is a growing realization that chronic obstructive pulmonary disease involves several processes present in aging and cellular senescence. The impact of these processes in the pathogenesis of the main manifestations is multiple, particularly in the propagation of a proinflammatory phenotype, loss of reparative potential, and amplification of oxidative stress, all ultimately leading to tissue damage. This review highlights salient aspects related to senescence discussed in the 2011 Aspen Lung ...[more]

PMID: 22550244

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