Ontology highlight
ABSTRACT:
SUBMITTER: Moen EL
PROVIDER: S-EPMC3360604 | biostudies-other | 2012
REPOSITORIES: biostudies-other
Moen Erika L EL Wen Sicheng S Anwar Talha T Cross-Knorr Sam S Brilliant Kate K Birnbaum Faith F Rahaman Sherida S Sedivy John M JM Moss Steven F SF Chatterjee Devasis D
PloS one 20120525 5
Helicobacter pylori (H. pylori) is a gram-negative, spiral-shaped bacterium that infects more than half of the world's population and is a major cause of gastric adenocarcinoma. The mechanisms that link H. pylori infection to gastric carcinogenesis are not well understood. In the present study, we report that the Raf-kinase inhibitor protein (RKIP) has a role in the induction of apoptosis by H. pylori in gastric epithelial cells. Western blot and luciferase transcription reporter assays demonstr ...[more]