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A wireless handheld probe with spectrally constrained evolution strategies for diffuse optical imaging of tissue.


ABSTRACT: We present a low-cost, portable, wireless diffuse optical imaging device. The handheld device is fast, portable, and can be applied to a wide range of both static and dynamic imaging applications including breast cancer, functional brain imaging, and peripheral artery disease. The continuous-wave probe has four near-infrared wavelengths and uses digital detection techniques to perform measurements at 2.3 Hz. Using a multispectral evolution algorithm for chromophore reconstruction, we can measure absolute oxygenated and deoxygenated hemoglobin concentration as well as scattering in tissue. Performance of the device is demonstrated using a series of liquid phantoms comprised of Intralipid(®), ink, and dye.

SUBMITTER: Flexman ML 

PROVIDER: S-EPMC3360692 | biostudies-other | 2012 Mar

REPOSITORIES: biostudies-other

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