Ontology highlight
ABSTRACT:
SUBMITTER: Chang JH
PROVIDER: S-EPMC3361639 | biostudies-other | 2012 May
REPOSITORIES: biostudies-other
Chang Jae-Hoon JH Xiao Yichuan Y Hu Hongbo H Jin Jin J Yu Jiayi J Zhou Xiaofei X Wu Xuefeng X Johnson Howard M HM Akira Shizuo S Pasparakis Manolis M Cheng Xuhong X Sun Shao-Cong SC
Nature immunology 20120501 5
The maintenance of immune homeostasis requires regulatory T cells (Treg cells). Here we found that Treg cell–specific ablation of Ubc13, a Lys63 (K63)-specific ubiquitin-conjugating enzyme, caused aberrant T cell activation and autoimmunity. Although Ubc13 deficiency did not affect the survival of Treg cells or expression of the transcription factor Foxp3, it impaired the in vivo suppressive function of Treg cells and rendered them sensitive to the acquisition of T helper type 1 (TH1) cell– and ...[more]