Pathophysiology of pulmonary hypertension in acute lung injury.
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ABSTRACT:
SUBMITTER: Price LC
PROVIDER: S-EPMC3362157 | biostudies-other | 2012 May
REPOSITORIES: biostudies-other
Publications
Pathophysiology of pulmonary hypertension in acute lung injury.
Price Laura C LC McAuley Danny F DF Marino Philip S PS Finney Simon J SJ Griffiths Mark J MJ Wort Stephen John SJ
American journal of physiology. Lung cellular and molecular physiology 20120113 9
Acute lung injury (ALI) and acute respiratory distress syndrome are characterized by protein rich alveolar edema, reduced lung compliance, and acute severe hypoxemia. A degree of pulmonary hypertension (PH) is also characteristic, higher levels of which are associated with increased morbidity and mortality. The increase in right ventricular (RV) afterload causes RV dysfunction and failure in some patients, with associated adverse effects on oxygen delivery. Although the introduction of lung prot ...[more]
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