Ontology highlight
ABSTRACT:
SUBMITTER: Rousseau L
PROVIDER: S-EPMC3362579 | biostudies-other | 2012
REPOSITORIES: biostudies-other
Rousseau Laure L Etienne Olivier O Roque Telma T Desmaze Chantal C Haton Céline C Mouthon Marc-André MA Bernardino-Sgherri Jacqueline J Essers Jeroen J Kanaar Roland R Boussin François D FD
PloS one 20120529 5
We characterized the in vivo importance of the homologous recombination factor RAD54 for the developing mouse brain cortex in normal conditions or after ionizing radiation exposure. Contrary to numerous homologous recombination genes, Rad54 disruption did not impact the cortical development without exogenous stress, but it dramatically enhanced the radiation sensitivity of neural stem and progenitor cells. This resulted in the death of all cells irradiated during S or G2, whereas the viability o ...[more]