Ontology highlight
ABSTRACT:
SUBMITTER: Oh S
PROVIDER: S-EPMC3362686 | biostudies-other | 2012 Aug
REPOSITORIES: biostudies-other
Oh Sangphil S Shin Sook S Janknecht Ralf R
Biochimica et biophysica acta 20120308 1
The homologous ETV1, ETV4 and ETV5 proteins form the PEA3 subfamily of ETS transcription factors. In Ewing tumors, chromosomal translocations affecting ETV1 or ETV4 are an underlying cause of carcinogenesis. Likewise, chromosomal rearrangements of the ETV1, ETV4 or ETV5 gene occur in prostate tumors and are thought to be one of the major driving forces in the genesis of prostate cancer. In addition, these three ETS proteins are implicated in melanomas, breast and other types of cancer. Complex p ...[more]