Ontology highlight
ABSTRACT:
SUBMITTER: Boulter L
PROVIDER: S-EPMC3364717 | biostudies-other | 2012 Mar
REPOSITORIES: biostudies-other
Boulter Luke L Govaere Olivier O Bird Tom G TG Radulescu Sorina S Ramachandran Prakash P Pellicoro Antonella A Ridgway Rachel A RA Seo Sang Soo SS Spee Bart B Van Rooijen Nico N Sansom Owen J OJ Iredale John P JP Lowell Sally S Roskams Tania T Forbes Stuart J SJ
Nature medicine 20120304 4
During chronic injury a population of bipotent hepatic progenitor cells (HPCs) become activated to regenerate both cholangiocytes and hepatocytes. Here we show in human diseased liver and mouse models of the ductular reaction that Notch and Wnt signaling direct specification of HPCs via their interactions with activated myofibroblasts or macrophages. In particular, we found that during biliary regeneration, expression of Jagged 1 (a Notch ligand) by myofibroblasts promoted No ...[more]