Ontology highlight
ABSTRACT:
SUBMITTER: Poillot C
PROVIDER: S-EPMC3366825 | biostudies-other | 2012 May
REPOSITORIES: biostudies-other
Poillot Cathy C Bichraoui Hicham H Tisseyre Céline C Bahemberae Eloi E Andreotti Nicolas N Sabatier Jean-Marc JM Ronjat Michel M De Waard Michel M
The Journal of biological chemistry 20120320 21
Maurocalcine is the first demonstrated example of an animal toxin peptide with efficient cell penetration properties. Although it is a highly competitive cell-penetrating peptide (CPP), its relatively large size of 33 amino acids and the presence of three internal disulfide bridges may hamper its development for in vitro and in vivo applications. Here, we demonstrate that several efficient CPPs can be derived from maurocalcine by replacing Cys residues by isosteric 2-aminobutyric acid residues a ...[more]