Ontology highlight
ABSTRACT:
SUBMITTER: Lohmueller JJ
PROVIDER: S-EPMC3367183 | biostudies-other | 2012 Jun
REPOSITORIES: biostudies-other
Lohmueller Jason J JJ Armel Thomas Z TZ Silver Pamela A PA
Nucleic acids research 20120209 11
The ability to perform molecular-level computation in mammalian cells has the potential to enable a new wave of sophisticated cell-based therapies and diagnostics. To this end, we developed a Boolean logic framework utilizing artificial Cys(2)-His(2) zinc finger transcription factors (ZF-TFs) as computing elements. Artificial ZFs can be designed to specifically bind different DNA sequences and thus comprise a diverse set of components ideal for the construction of scalable networks. We generate ...[more]